Helping Children Meet Their Full Potential Faster
For many families in Michigan, one of the toughest parts of autism spectrum disorder (ASD) is delayed speech. It can be heartbreaking to wait for your child to express needs or say simple words.
At Caliber Autism in Troy, MI, we understand these challenges. Our team is dedicated to exploring therapies that help children with autism unlock their potential. One treatment gaining attention is leucovorin (folinic acid): a folate-based therapy that may improve language and communication.
Leucovorin is a form of folate often used in medicine to support patients after chemotherapy. In recent years, researchers have studied its role in autism therapy. Early findings suggest that leucovorin may enhance speech and communication in children with autism, particularly those with specific challenges in folate metabolism.
Folate (vitamin B9) is essential for brain development. But many children with ASD have cerebral folate deficiency, often linked to antibodies that block folate receptors in the brain. These folate receptor autoantibodies (FRAA) are present in up to 70% of children with autism, compared to only 5–10% of the general population.
When folate cannot enter the brain, speech, language, and learning are affected.
Leucovorin (folinic acid) bypasses the blocked folate receptors by using an alternative pathway, restoring folate levels in the brain. Unlike regular folic acid supplements, high-dose leucovorin can cross the blood-brain barrier and support healthy brain function.
Research studies using leucovorin have reported:
Stronger language skills
Improved social interaction
Better developmental progress
Typical dosing ranges from 0.5 to 2 mg per kg of body weight daily, up to 50 mg/day, always under medical supervision.
Leucovorin is generally safe for children. Some individuals may experience increased energy or restlessness during the first few weeks, which typically resolves within 6 to 9 weeks. Gradual dosing helps reduce these effects. No significant concerns have been reported in lab tests for blood, liver, or kidney function.
At Caliber Autism & Pediatric Therapy in Troy, MI, we combine innovative biomedical treatments, such as leucovorin, with proven speech, ABA, and developmental therapies. Our goal is to help children communicate, grow, and thrive.
If you’re curious whether leucovorin could support your child, we’re here to guide you. Families across Oakland County and Metro Detroit trust Caliber for personalized, compassionate care.
Schedule a consultation today, and let’s explore the best path forward for your child.
